J. Fawcett, N. Camerman, A. Camerman
Oct 15, 1977
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0
Influential Citations
6
Citations
Journal
Canadian Journal of Chemistry
Abstract
The crystal and molecular structure of diphenylsilanediol, a compound with recently demonstrated anticonvulsant activity, has been determined and its stereochemistry compared with other antiepileptics. Crystals of diphenylsilanediol are triclinic, space group with cell dimensions a = 9.912, b = 15.048, c = 14.519 A, α = 120.83,β = 99.95, γ = 100.84°, Z = 6 molecules per cell (3 molecules per asymmetric unit). The structure was determined by Patterson and Fourier methods and refined to a final discrepancy value R = 0.034. The phenyl ring planes in the molecule are rotated by 80° with respect to each other, and the hydroxyl oxygen atoms are 2.66 A apart. The molecular parameters help to delineate limits of stereochemical variation in these molecules with retention of anticonvulsant activity.