Julie A. Harris, M. Carducci, P. Myrdal
Nov 1, 2003
Citations
0
Influential Citations
8
Citations
Journal
Acta Crystallographica Section E-structure Reports Online
Abstract
Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C28H37ClO7·2C2H6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.