Min Chen, Qing Zhao, Jun-di Hao
Feb 1, 2017
Citations
0
Influential Citations
8
Citations
Journal
Natural Product Research
Abstract
Abstract Two new benzaldehyde derivatives, named 3′-OH-tetrahydroauroglaucin (1) and(3′S*,4′R*)-6-(3′,5-epoxy-4′-hydroxy-1′-heptenyl)-2-hydroxy-3-(3′′-methyl-2′′-butenyl)benzaldehyde (2), were isolated from a gorgonian-derived Eurotium sp. fungus. Their structures were determined by extensive spectroscopic analysis including NMR and MS spectra. Dissolved 1 in CDCl3 for several days could be detected its 2H-chromene skeleton derivatives (1a/1b), a pair of enantiomers with opposite configurations at C-3′. Compound 2 was also found to chemically convert to a pair of epimers non-enzymatically. The plausible mechanism to form the 2H-chromene artefacts with racemisation at C-3′ undergoing nucleophilic substitution (SN1) was proposed.