M. Prichard, Sam L. Frederick, S. Daily
Feb 7, 2011
Citations
0
Influential Citations
15
Citations
Journal
Antimicrobial Agents and Chemotherapy
Abstract
ABSTRACT Several benzimidazole nucleoside analogs, including 1H-β-d-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-l-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of these compounds were evaluated against both variants of HHV-6, and two l-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more modest inhibition of HHV-6B replication.