Abdelaaziz Ouahrouch, H. Ighachane, M. Taourirte
Aug 4, 2014
Citations
1
Influential Citations
33
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Quality indicators
Journal
Archiv Der Pharmazie
Abstract
A novel series of hybrid molecules 4a–i and 5a–i were prepared by condensation of 4‐(trimethylsilylethynyl)benzaldehyde 1 with substituted o‐phenylenediamines. These in turn were reacted with 2‐(azidomethoxy)ethyl acetate in a Cu alkyne–azide cycloaddition (CuAAC) to generate the 1,2,3‐triazole pharmacophore under microwave assistance. The newly synthesized compounds were examined for their in vitro antimicrobial activities against Gram‐positive and Gram‐negative bacteria and the phytopathogenic fungi Verticillium dahliae and Fusarium oxysporum f. sp. albedinis. 2‐((4‐(4‐(5‐Trifluoromethyl benzimidazol‐2‐yl)phenyl)‐1,2,3‐triazol‐1‐yl)methoxy)ethanol 5e showed a moderate inhibition of 30% in the Foa sporulation test.