Hua Erbin
2013
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Influential Citations
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Citations
Quality indicators
Journal
Journal of Tianjin University of Science and Technology
Abstract
The effect of benzothiazole derivatives TJ-1(3-(benzo[d]thiazol-2-yl)benzenamine),TJ-2(N-(3-(benzo[d] thiazol-2-yl)phenyl)-3,4,5-trimethoxybenzamide),and TJ-3(N-(3-(benzo[d]thiazol-2-yl)phenyl)-1,H-pyrazole-3-carboxamide) on the antioxidating activities of mice with high fat diet was studied. Fifty 8-week-old male C57BL/6,J mice were quarantined for 1 week. They were then randomly assigned to the following five groups according to body weight:high fat diet group,resveratrol control group,TJ-1,group,TJ-2 group and TJ-3 group. The levels of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px),catalase(CAT)and malondialdehyde(MDA)were measured after the treatment which lasted for 12 weeks. Compared with the high fat diet group,the SOD,GSH-Px and CAT levels in the serum,liver and brain of the other 4 groups were higher,and the MDA levels were lower. Benzothiazole derivatives can improve the antioxidating activities of high fat mice.