T. Mizuno, J. Takahashi, A. Ogawa
Dec 9, 2002
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron
Abstract
Abstract A novel non-phosgene synthetic method for benzyl chloroformate (CbzCl) was established. S -Methyl O -benzyl carbonothioates were prepared by the carbonylation of benzyl alcohols with carbon monoxide and sulfur (or carbonyl sulfide) in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) followed by esterification using methyl iodide in good yields. Then, CbzCl derivatives were successfully synthesized by the chlorination of S -methyl O -benzyl carbonothioates using sulfuryl chloride in excellent yields.