G. H. Hamor, D. Breslow, G. Fisch
Dec 1, 1970
Citations
0
Influential Citations
8
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The synthesis of some 26 O-substituted hydroxylamine derivatives is described.Potent anti-inflammatory activity in the carrageenin-induced rat paw edema test is shown by m-nitrobenzyl-oxyamine hydrochloride and by p-nitrobenzyloxyamine hydrochloride.Moreover, p-nitrobenzyloxyamine hydrochloride also possesses potent inhibitory activity when tested in vitroagainst the histamine-forming enzyme, specific histidine decarboxylase, thus lending additional support to the theory linking histamine to the inflammatory process.Further evidence is given for the bioisosterism of the nitrobenzene and pyridine moieties.The necessity of a free aminooxy group for anti-inflammatory activity is demonstrated.