H. Ohtaka, M. Miyake, T. Kanazawa
Jul 25, 1987
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0
Influential Citations
5
Citations
Quality indicators
Journal
Chemical & pharmaceutical bulletin
Abstract
A series of 1- (2, 3, 4-trimethoxybenzyl) piperazine (trimetazidine) derivatives were prepared and tested for cerebral vasodilating activity. Almost all the compounds possess stronger activity than trimetazidine and among them, the γ-amino tertiary alcohols 6e-j exhibit potent cerebral vasodilating activities which are superior to those of cinnarizine and papaverine. Moreover, these compounds show a selective vasodilating effect on vertebral arteries.