Gilfrich Hj, Rahn Kh, Nicolescu Rf
Sep 1, 1971
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
European Journal of Clinical Pharmacology
Abstract
The beta-adrenergic blocking activity and haemodynamic effects of o-[2-hydroxy-3-(isopropylamino)-propoxy]-benzonitril (Ko 1313) have been studied in 22 patients. Antagonism of isoproterenol-induced tachycardia was used as a measure of the beta-adrenergic blocking activity. Ko 1313 1.0 mg had its maximum beta-adrenoceptor blocking effect 5–30 min after intravenous injection. Ko 1313 10.0 mg produced maximum betablockade 1–4 h after oral administration. 1.0 mg Ko 1313 injected intravenously had approximately the same beta-adrenergic blocking effect as 1.0 mg propranolol also given intravenously. After intravenous administration Ko 1313 was 3–4 times as potent as the same dose given orally. An intravenous dose of 2.0 mg Ko 1313 reduced the heart rate and produced insignificant fall in cardiac output. Total peripheral resistance was increased by Ko 1313.