M. Hoefle, S. Hastings, R. F. Meyer
Feb 1, 1975
Citations
0
Influential Citations
51
Citations
Journal
Journal of medicinal chemistry
Abstract
A series of 1-amino-3-aryloxy-2-propanols has been synthesized and examined for cardioselective beta-blockade. The introduction of the (3,4-dimethoxyphenethyl)amino group lead to the most cardioselective agents. Structure-activity relationships are discussed. Of the compounds tested 1-[(3,4-dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol was selected for clinical trial because of optimal potency and selectivity.