Masaoki Yamamoto, Y. Takayanagi, Susumu Nihashi
1995
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0
Influential Citations
5
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Journal
Chirality
Abstract
Synthesis of (−)-bevantolol hydrochloride from 3,4-dimethoxyphenethylamine and (S)-(+)-m-tolyl glycidyl ether derived from (R)-(−)-epichlorohydrin established the absolute configuration of the (+) and (−) enantiomer as R and S, respectively. The purity of the enantiomers was determines using a chiral cellulose column (CHIRALCEL OD®) which allowed direct separation of the enantiomers. A separation factor (α) of 4.20 and a resolution factor (Rs) of 9.21 were obtained. © 1995 Wiley-Liss, Inc.