H. Binder, C. Filburn, B. Volpe
Mar 1, 1975
Citations
1
Influential Citations
144
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Quality indicators
Journal
Gastroenterology
Abstract
Previous studies of the mechanism of bile salt stimulation of electrolyte secretion in the colon resulted in the suggestion that cyclic AMP may be the intracellular mediator of bile salt-induced secretion. In these studies, cyclic AMP levels were measured and the effect of dibutyryl cyclic AMP on sodium transport was determined. Colonic mucosal cyclic AMP levels in the rat increased by 54% after in vivo incubations with taurochenodeoxycholic acid. Taurocholic acid, which neither induces fluid secretion nor increases short circuit current at concentrations at which taurochenodeoxycholic acid will increase both fluid secretion and short circuit current, does not alter mucosal cyclic AMP. Dibutyryl cyclic AMP decreased net sodium absorption and increased short circuit current; findings which were qualitatively identical to those produced by taurochenodeoxycholic acid. These studies support the proposal that bile salts stimulate colonic electrolyte secretion by increasing mucosal cyclic AMP.