R. Haque, J. Deagen, F. J. Biros
Apr 1, 1976
Citations
0
Influential Citations
4
Citations
Journal
Pesticide Biochemistry and Physiology
Abstract
Abstract The binding of bis( p -chlorophenyl) acetic acid with bovine serum albumin has been monitored by observing the changes in the relaxation times of bis( p -chlorophenyl) acetic acid proton magnetic resonance peaks. The addition of bovine serum albumin to an aqueous solution of bis( p -chlorophenyl) acetic acid increased linewidths in a manner suggesting rapid, reversible binding. Line broadening was found to be greater for the ring protons than for the benzylic proton, indicating that the ring presents the stronger binding site. The equilibrium constant has been approximated. The binding results are discussed in terms of environmental and toxicological considerations.