J. Biggs, L. Levy
Jun 1, 1971
Citations
0
Influential Citations
14
Citations
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary Binding of dapsone and monoacetyldapsone to human plasma proteins has been investigated by means of an ultrafiltration technique. When binding was studied in vivo or in vitro at therapeutic concentrations of the drugs, dapsone was 70 to 80% bound, and monoacetyldapsone 98 to 100%. Rapid and slow acetylators of dapsone bind both compounds to the same degree. Protein binding of monoacetyldapsone may well account for the limited excretion of this compound in the urine. The contribution of protein binding to the long plasma half-lives of these compounds must be evaluated in the light of future studies.