T. Kuroki, E. Huberman, H. Marquardt
May 1, 1972
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0
Influential Citations
79
Citations
Quality indicators
Journal
Chemico-biological interactions
Abstract
Abstract The firm binding of benz[a]anthracene and dibenz[a,h]anthracene and their K-region epoxides, cis -dihydrodiols, and phenols to the DNA, RNA, and proteins of exponentially growing cells has been studied. In hamster embryonic cells that undergo malignant transformation, the epoxide of benz[a]anthracene was bound to all macromolecules to a much greater extent than the hydrocarbon and other derivatives. The binding to DNA reached its maximum at 3 h. In the dibenz[a,h]anthracene series, the epoxide was highly bound to RNA and protein, but only to a small extent to DNA. The extent of binding of all compounds to DNA, RNA, and proteins of transformable G23 cells was less than to hamster cels, and the binding to malignant T24 cells was very much lower. The relationship of metabolism to binding and carcinogenesis is discussed.