J. Judis
Aug 1, 1981
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Journal of Pharmaceutical Sciences
Abstract
Prostaglandins E1 (alprostadil), E2 (dinoprostone), F1a, and F2a (dinoprost) were characterized in terms of binding to human serum, albumin, γ-globulin II, β-globulin III, α-globulin IV-1, and α-globulin IV-4. By using equilibrium dialysis and tritium-labeled ligands, the percent binding for all four ligands was found to decrease in the following order: human serum, albumin, and α-globulin IV-4. For the other three proteins, the order was not consistent with the four ligands, and <10% binding was observed. In general, prostaglandins E1 and E2 showed a higher percent binding for all fractions than prostaglandins F1a and F2a. All four ligands can be characterized as showing significant binding to human serum, albumin, and α-globulin IV-4.