M. Leutbecher, M. Cornet, S. Regier
2009
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Archives of Toxicology
Abstract
2-Methylpropene (isobutene), a basic petrochemical product, is metabolized by hepatic monooxygenase to its epoxide, 2,2-dimethyloxirane (Csamidy et al. 1991; Comet et al. 1991), which is weakly mutagenic in S. typhimurium TA 100, TA 102 and especially TA 1535 (Comet et al. 1992). In order to evaluate the potential genotoxicity of 2-methylpropene in vivo, a DNA binding study was performed in male and female F-344 rats and B6C3F1 mice with inhaled [1,3-14C]2-methylpropene. The study was performed concurrently with a similar study with [14C]ethylene oxide in rats (Bolt and Leutbecher 1993). The following groups of animals were placed in the closed all-glass exposure system of Bolt et al. (1976), volume 10.2 1, containing 200 g soda lime: