Qian Wang, Zhixue Liu, Ying‐Ming Zhang
Oct 21, 2019
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Abstract
Selective binding of cyclodextrins (CDs) with guests has become one of the research hotspots in modern supramolecular chemistry. Investigation on the binding behaviors and thermodynamics of CD derivatives to bile acids is of great scientific significance for understanding the host-guest recognition mechanism and thermodynamic origins. Thus, this review will focus on the binding mode, binding ability, molecular selectivity and binding thermodynamics of glycine, tryptophan, tyrosine and its decarboxylated derivatives modified CDs with a series of bile acid guests, i.e., cholate (CA), deoxycholate (DCA), chenodeoxycholate (CDCA), glycocholate (GCA) and taurocholate (TCA), as well as their potential applications in the clearance of bile acids in human body, regulation of the bile acids balance, treatment of diseases, which will facilitate the molecular-level understanding of the molecular recognition mechanism and eventually promote the development of supramolecular chemistry.