G. Stoner, H. Schut
1985
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Quality indicators
Journal
Journal name not available for this finding
Abstract
Abstract : Two dye compounds, C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3-C.I. Solvent Yellow 33, utilized in colored smoke grenades, were tested for carcinogenic potential in the strain A mouse lung tumor bioassay. The maximum tolerated dose for each dye was determined to be 25 mg/kg. At total doses of 600, 300 and 120 mg/kg, C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3-C.I. Solvent Yellow 33 did not produce an increase in the lung tumor response (i.e., the percentage of mice with lung tumors or the mean number of lung tumors per mouse) when compared to vehicle (tricaprylin) controls. Therefore, at the dose levels administered both dyes were non-carcinogenic in the strain A mouse lung tumor bioassay under the conditions of the test. At necropsy, mice tested with either compound had significant quantities of accumulated dye in their tissues. This observation suggests that the dyes were either not metabolized or only partially metabolized by the animals.