Jennifer T. Nguyen, Kennedy K. Riebschleger, K. Brown
Oct 30, 2021
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0
Influential Citations
3
Citations
Journal
Biotechnology Journal
Abstract
The tetracenomycins are aromatic anticancer polyketides that inhibit peptide translation via binding to the large ribosomal subunit. Here, we expressed the elloramycin biosynthetic gene cluster in the heterologous host Streptomyces coelicolor M1146 to facilitate the downstream production of tetracenomycin analogs.