E. Boyland, P. Sims
Oct 1, 1959
Citations
0
Influential Citations
8
Citations
Journal
The Biochemical journal
Abstract
3:4-Dimethylaniline is one of the simplest aromatic amines with carcinogenic properties. Morris, Lombard, Wagner & Weisburger (1957) showed that increases in the incidence of pituitary gland tumours occur when the amine is fed to rats, and Woolley (1953) and Woolley & Schaffner (1954) showed that the related o-aminophenol, 2-amino4:5-dimethylphenol, causes a transient regression of spontaneous mammary tumours in mice. Allen, Boyland, Dukes, Homing & Watson (1957) showed that tumours are produced when pellets of the aminophenol and cholesterol are implanted in the bladders of mice. The metabolism of 3:4-dimethylaniline and of its N-acetyl derivative in rats is described below.