Brijesh Kumar Srivastava, R. Soni, A. Joharapurkar
Feb 1, 2008
Citations
0
Influential Citations
11
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Design, synthesis and conformational analysis of few imidazole and oxazole as bioisosters of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) 2 is reported. Computer assisted conformational analysis gave a direct clue for the loss of CB1 antagonistic activity of the ligands without a fine docking simulation for the homology model.