C. Barbieri, L. Bossi, P. D’Arrigo
Jan 22, 2001
Citations
1
Influential Citations
30
Citations
Journal
Journal of Molecular Catalysis B-enzymatic
Abstract
Abstract Substituted phenacyl chlorides are reduced with whole-cell biocatalysts to give ( R )- or ( S )-chlorohydrines in high yields and to make them good for high enantiomeric excess. Yields and enantiomeric purity of the S -enantiomer could be increased by performing bioreduction in the presence of polymeric absorbing resins. With this methodology, 2-chloro-1( S )-(3,4-dichloro-phenyl)-ethanol of 98% e.e. and 2-( R )-(4-nitro-phenyl)-ethanol of 92% e.e. have been prepared and used respectively as precursors in the synthesis of (+)- cis -1( S ),4( S )-sertraline and of the β-blocker ( R )-nifenalol®.