N. Abe, Tadaharu Arakawa, Kazunobu Yamamoto
Jan 1, 2002
Citations
0
Influential Citations
30
Citations
Journal
Bioscience, Biotechnology, and Biochemistry
Abstract
An incorporation study of [1-13C] and [1,2-13C2] labeled sodium acetates into sorbicillinol 1 established a ring closure system between C-1 and C-6 and the positions that were oxidized and/or methylated on a hexaketide chain. Subsequent investigations, using 13C-labeled 1 prepared from [1-13C] labeled sodium acetate, clearly demonstrated that both bisorbicillinol 2 and sorbicillin 6 incorporated 13C-labeled 1 into their carbon skeletons. 13C-labeled bisorbicillinols 2 derived from [1-13C]- and [2-13C]-labeled sodium acetates clearly indicate that these were on the biosynthetic route from 1 to bisorbibutenolide (bislongiquinolide) 3 and bisorbicillinolide 4 via 2 as a branching point in the fungus.