L. Nover, M. Luckner
Sep 1, 1969
Citations
0
Influential Citations
46
Citations
Journal
European journal of biochemistry
Abstract
By feeding of isotope labelled compounds to cultures of Penicillium cyclopium Westling and degradation of the cyclopenin (3-benzyl-3,10-epoxy-4-methyl-2,3,4,5-tetrahydro-1 H-1,4-benzodiazepine-2,5-dione) and cyclopenol [3-(m-hydroxy-benzyl)-3,10-epoxy-4-methyl-2,3,4,5-tetrahydro-1 H-1,4-benzodiazepine-2,5-dione] formed the biosynthesis of these alkaloids was investigated: 1 The carbon skeletons of both alkaloids originate from all the C-atoms of anthranilic acid and l-phenylalanine and from the methyl group of methionine. 2 N(1) and N(4) of the diazepine ring derive from all the nitrogen atoms of anthranilic acid and l-phenylalanine respectively. 3 For cyclopenol, of several phenylpropane compounds tested, only l-phenylalanine is a direct precursor. Thus, the introduction of the m-hydroxy group by a mixed functional oxygenase as one of the later steps of its biosynthesis appears very likely.