U. Hanefeld, H. Floss, H. Laatsch
Jul 1, 1994
Citations
2
Influential Citations
41
Citations
Journal
Journal of Organic Chemistry
Abstract
The biosynthesis of the potent marine antibiotic, pentabromopseudilin (1), was investigated in Afteromonas luteoviofaceus grown in a complex medium by feeding experiments with 13 C-acetate, various amino acids, and differently labeled glucoses. The results show that the benzene ring of 1 originates from the shikimate pathway via p-hydroxybenzoic acid as a direct precursor. No incorporation of 13 C into the pyrrole ring was observed in any of these experiments