H. Ristow, J. Salnikow, H. Kleinkauf
Jun 1, 1974
Citations
0
Influential Citations
20
Citations
Journal
FEBS Letters
Abstract
Received 29 March 1974 1. Introduction Valinomycin is a cyclododecadepsipeptide consis- ting of three residues each of L-valine, ~-D-hydroxy- isovaleric acid, D-valine and L-lactic acid joined to- gether by alternating amide and ester linkages [1 ]. The results on the biosynthesis of gramicidin S [2], tyrocidine [3] and alamethicin [4] suggest that valinomycin is formed by a similar non-ribosomal pep- tide synthesizing mechanism. In this report we des- cribe the isolation of an enzyme complex that is ca- pable of synthesizing the complete molecule of valino- mycin from the precursors L-valine and L-alanine or L-threonine.