S. Pfeifer, P. Franke
1985
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Quality indicators
Journal
Die Pharmazie
Abstract
After application of chlorophenethazine more than 20 metabolites were detected in rat urine. The structure of 14 metabolites were elucidated (UV, MS), which are hydroxy, N-dealkyl, S-oxide, sulfone and N-oxid derivatives. The hydroxy derivatives are partly conjugated. The relative high content of the sulfone of 2-chlorophenothiazine-N-acetic acid (upto 10% of the total metabolite content) is remarkable. Main metabolites are the S-oxide of the N-dealkyl derivative and 7-hydroxy-1.