W. L. Veer, P. Oud
Sep 2, 2010
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Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
The synthesis of the hitherto unknown 2-phenyl-cyclohexene-l-carboxylic acid and 2-cyclohexyl-cyclohexene(1 or 6)-carboxylic acid is described. These acids, as well as 2-phenylbenzoic acid, trans-2-phenyl-cyclohexane carboxylic acid, 2-cyclohexyl benzoic acid, 2-cyclohexyl-cyclohexane carboxylic acid and biphenyl-2-acetic acid were converted into their tertiary aminoalkyl esters. These esters exhibit various pharmacological properties, the antispasmodic activity being most pronounced. In this respect (2-dimethylaminoethyl)-2-phenyl-cyclohexene-l-carboxylate and (2-diethylaminoethyl)-trans-2-phenyl-cyclohexane carboxylate are the most powerful compounds of the series.