N. Ueberschaar, F. Meyer, H. Dahse
Mar 24, 2016
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0
Influential Citations
4
Citations
Journal
Chemical communications
Abstract
DNA-intercalating polyketide glycosides are important leads for cancer therapeutics, yet their use is often limited by their low solubility and challenging synthetic protocols. To overcome these limitations, we employed 1,4'-bipiperidine-1'-carbamate residues as sugar surrogates in daunorubicin and chartreusin, yielding water-soluble derivatives and prodrugs with dramatically improved antiproliferative activities.