Matthias Lotz, B. Pugin, M. Kesselgruber
May 17, 2010
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Influential Citations
6
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Journal
Tetrahedron-asymmetry
Abstract
The bis(2-methoxymethyl pyrrolidine)phosphine moiety is shown to be a very effective chiral auxiliary for the ortho- and diastereoselective lithiation of ferrocene, thereby allowing the highly selective attachment of various electrophiles to the cyclopentadienyl ring of ferrocene. The potential of the methodology is demonstrated by the synthesis of Kephos, a new family of ferrocenyl diphosphines and of OH-Taniaphos derivatives.