Xiao-Li Cheng, Hanxiang Li, Ping Wu
Feb 1, 2019
Citations
0
Influential Citations
4
Citations
Journal
Phytochemistry Letters
Abstract
Abstract Two new bisabolane-type sesquiterpenoids, (3R,4S,5R,7S)-3,4,5-trihydroxybisabola-10-ene-9-one (1), (1R,2S,5R,7R,8S)-2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), together with seven known anologues (3–9), were isolated from the cooking liquid of Curcuma longa rhizomes. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. The absolute configurations of compounds 1 and 2 were assigned by electronic circular dichroism (ECD) calculations. Compound 2 exhibited in vitro anti-inflammatory activity with an IC50 value of 25.5 ± 3.1 μM comparable to that of the positive control.