Xing Li, C. Huo, Yuan-ting Xiao
Aug 12, 2019
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Influential Citations
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Quality indicators
Journal
Chemical research in toxicology
Abstract
Bisdemethoxycurcumin (BDMC) is one of three curcuminoids extracted from turmeric. Unlike the dominant ingredient curcumin with some intensive investigations, BDMC was recently reported to possess potent anti-tumor, anti-inflammatory, anti-atherosclerosis, anti-obesity and anti-ageing effects. Considering its pharmacological effects in inflammation, atherosclerosis and obesity, this study was designed to examine if BDMC displays cardioprotective property. In this study, staurosporine (STS) was used to establish cardiomyocyte injury model. Our data revealed that BDMC significantly inhibited myocardial apoptosis, improved cell survival, reduced caspase-3 activity and diminished reactive oxygen species (ROS) production. BDMC enhanced phosphorylation of protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) and up-regulated the expression of HO-1. Inhibition of HO-1 activity by using tin-protoporphyrin (SnPPIX) can restrain the anti-apoptotic effect of BDMC. Furthermore, translocation of Nrf2 from cytoplasm to nucleus was ablated by LY294002, although only partially by PD98059. Up-regulation of HO-1 was weakly suppressed by PD98059 but strongly inhibited by LY294002. Unlike PD98059, LY294002 negated the protective effect of BDMC. These findings indicated that BDMC possessed favorable cardioprotection in a Nrf2 / HO-1-dependent manner. Activation of Nrf2 /HO-1 mainly depended on PI3K / AKT but not MEK/ERK signaling.