S. Sparapani, Stefania Bellini, M. Gunaratnam
Jul 28, 2010
Citations
0
Influential Citations
20
Citations
Journal
Chemical communications
Abstract
A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.