W. Stec, B. Uznański, A. Wilk
Aug 13, 1993
Citations
0
Influential Citations
67
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A new sulfurizing reagent is reported for the automated synthesis of phosphothioate analogues of oligonucloetides via the phosphoramidite method. Bis(O,diisopropoxy phosphinothioyl) disulfide (S-Tetra, 1 ) is relatively inexpensive to prepare, easy to handle, and efficiently sulfurizes internucleotide phosphites, thus allowing the practical synthesis of oligo(nucleoside phosphorothioate)s with exceptionally high sulfur content.