J. Timmerman, J. P. Long, C. Pittinger
May 1, 1959
Citations
0
Influential Citations
64
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract Neomycin sulfate, streptomycin sulfate, dihydrostreptomycin sulfate, polymyxin B sulfate, and kanamycin sulfate produced neuromuscular blockade in the rabbit at various dosage levels. The blocking action of these five drugs, with the exception of polymyxin B sulfate, was enhanced by the simultaneous administration of d -tubocurarine chloride. Neostigmine methylsulfate antagonized the neuromuscular blockade produced by neomycin sulfate, streptomycin sulfate, and dihydrostreptomycin sulfate. Neostigmine methylsulfate tended to enhance the neuromuscular blocking action of polymyxin B sulfate and kanamycin sulfate. Tetracycline HCl, ristocetin, oleandomycin, erythromycin, bacitracin and penicillin G potassium showed no neuromuscular blocking activity. All of the antibiotics, except potassium penicillin G and ristocetin, tended to cause hypotension.