J. Holden, S. Gatley, R. Hichwa
Dec 1, 1981
Citations
1
Influential Citations
80
Citations
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Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Abstract
The development of a tomographic method of measuring regional cerebral blood flow, based on positron-emission tomographic determination of the regional cerebral kinetics of fluoromethane (F-18) (methyl fluoride) is reported. The high Ostwald solubility of fluoromethane has allowed development of a blood-flow method that takes advantage of the decades of previous blood-flow investigations with inert tracers, yet provides tomographic determinations at a spatial resolution approaching those of methods based on regional tissue deposition of radioactivity. Refinements of the method are proceeding and with a variety of clinical and research applications.