A. di Biagio, R. Rosso, P. Monteforte
Jul 22, 2009
Citations
1
Influential Citations
19
Citations
Quality indicators
Journal
Journal of Medical Case Reports
Abstract
IntroductionTenofovir disoproxil fumarate (Viread®) is the only nucleotide reverse transcriptase inhibitor currently approved for the treatment of HIV. It is frequently prescribed not only for its efficacy but also for its decreased side effect profile compared with other nucleotide analogs. In addition, it is now increasingly recognized as a cause of acquired Fanconi's syndrome in individuals with HIV.Case presentationWe describe a 48-year-old woman infected with HIV, with chronic renal insufficiency, who developed Fanconi's syndrome after inclusion of tenofovir disoproxil fumarate in her antiretroviral therapy. A whole body bone scintigraphy was performed, revealing an abnormal distribution of radiotracer uptake, with characteristic changes compatible with osteomalacia. All symptoms disappeared after tenofovir discontinuation and mineral supplementation. No other explanation for the sudden and complete resolution of the bone disease was found.ConclusionThe case highlights the role of whole body bone scintigraphy in the diagnosis of tenofovir-related osteomalacia.