Wataru Muramatsu, Kimihiro Nakano, Chao‐Jun Li
Mar 12, 2014
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Influential Citations
36
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Journal
Organic & biomolecular chemistry
Abstract
We have developed a method for the sp(3) C-H bond functionalization of tetrahydroisoquinolines (THIQs) mediated by [bis(trifluoroacetoxy)iodo]benzene (PIFA). The treatment of the THIQs with various nucleophiles in the presence of PIFA in a green solvent alternative gave the coupled products, with a C-C, C-N, or quaternary carbon center in high yields.