Tobias Stopka, Leyre Marzo, Mercedes Zurro
Apr 20, 2015
Citations
1
Influential Citations
36
Citations
Journal
Angewandte Chemie
Abstract
Tricyclic dibenzoxepines and dibenzazepines are important therapeutic agents for the pharmaceutical industry and academic research. However, their syntheses are generally rather tedious, requiring several steps that involve a Wagner-Meerwein-type rearrangement under harsh conditions. Herein, we present the first copper(I)-catalyzed oxidative CH bond functionalization and ring expansion with TMSCHN2 to yield these important derivatives in a facile and straightforward way.