M. Adamczyk, Donald D. Johnson, R. E. Reddy
Jun 16, 2000
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Influential Citations
16
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Journal
Tetrahedron-asymmetry
Abstract
Abstract A one-pot reaction of (2 S ,5 R )-(−)- tert -butyl-[(2- tert -butoxycarbonyl)amino]-5-hydroxy-6-aminohexanoate 2b or ( S )-(−)- tert -butyl-[(2- tert -butoxycarbonyl)amino]-6-aminohexanoate 2c with ( S )-(−)- tert -butyl-6-bromo-[bis-(2- tert -butoxycarbonyl)amino]-5-oxohexanoate 5 in the presence of K 2 CO 3 in MeCN–MeOH followed by hydrolysis gave bone collagen cross-links, (+)-Pyd 1b or (+)-Dpd 1c , in 42–48% yield, respectively.