Xiaohu Deng, N. Mani
Feb 7, 2005
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Journal
Tetrahedron-asymmetry
Abstract
Abstract A practical synthesis of (R)-N-Boc-2-(2-hydroxyethyl)pyrrolidine in high enantiomeric purity is described. The synthesis involves BF3·Et2O-assisted ring opening of ethylene oxide by a homochiral carbanion (R)-3, which is derived from sparteine-mediated asymmetric deprotonative lithiation of 1-Boc-pyrrolidine.