G. Topall, H. Laborit
Nov 1, 1989
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Abstract— After mice had been treated with L‐tyrosine, O‐phospho‐L‐tyrosine, L‐tyrosine methyl ester or N‐acetyl‐L‐tyrosine, tyrosine was assayed by HPLC coupled with fluorometric detection. O‐Phospho‐L‐tyrosine behaved as a tyrosine prodrug after its hydrolysis by acid and alkaline phosphatases. After the intraperitoneal administration of O‐phospho‐L‐tyrosine or the methyl ester, there was a substantial increase in bioavailability in terms of the effect of tyrosine. The two prodrugs were as powerful as tyrosine following oral administration. N‐Acetyl‐L‐tyrosine was the least effective prodrug tested. The stability, solubility and bioavailability of O‐phospho‐L‐tyrosine are consistent with proposing it for use as a tyrosine prodrug. In addition, it can be used parenterally. The use of a tyrosine aminotransferase inhibitor is necessary for limiting the hepatic breakdown of tyrosine and for increasing its bioavailability.