M. Malathi, D. P. Chary
2019
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Journal
Rasayan Journal of Chemistry
Abstract
A simple and efficient method was developed to synthesize 5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(4(1-methyl-1H-pyrazole-5-yl)phenyl)methanone from Pyrrole-2-carboxaldehyde and 1-(chloromethyl)-2nitrobenzene as starting materials. A reagent tertbutoxybis(dimethylamino) methane (Bredereck’s reagent, TBDMAM) used for selective formation of chalcones. All the compounds obtained were characterized by different spectroscopic techniques such as IR, NMR and mass analysis. Molecular docking study of the synthesized compounds was showed the best fit with the minimum binding energies of -5.78 kcal/mol.