Q. Deng, Ruwei Shen, Ronghua Ding
Aug 1, 2016
Citations
0
Influential Citations
8
Citations
Journal
Chemical Engineering & Technology
Abstract
2,4,5-Trifluorobromobenzene is a valuable intermediate with important application in the synthesis of biologically active peptides and fluorescent reagents. A continuous-flow system has been successfully developed for the synthesis of 2,4,5-trifluorobromobenzene in a microreactor using FeBr3 as a catalyst, which is steadily generated in situ from the reaction of Br2 and Fe. The procedure is efficient and easy-to-handle, and 2,4,5-trifluorobromobenzene can be obtained within minutes in high yields.