Xu Yong-nan
2012
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Journal
Liaoning Chemical Industry
Abstract
Methyl 2-(2-bromo-4,5-dimethoxyphenyl)ethanoate was synthesized form methyl 2-(3,4-dimethoxyphenyl)ethanoate in yield of 94%.The optimum condition was as follows: the molar ratio of methyl 2-(3,4-dimethoxyphenyl)ethanoate and NBS was 1︰ 1,methanol was used as solvent,reaction temperature was room temperature,NBS was used as brominating agent instead of corrosive and toxic bromine.This method can be as a general approach of electrophilic aromatic bromination of the aromatic ethers.