Y. Miki*, Hideaki Umemoto, Maiko Nakamura
Sep 1, 2006
Citations
0
Influential Citations
10
Citations
Journal
Heterocycles
Abstract
Treatment of dimethyl indole-2,3-dicarboxylate with pyridinium hydrobromide perbromide or bromine in the presence of Lewis acid gave dimethyl 5-bromoindole-2,3-dicarboxylate as the sole product. In a similar manner, dimethyl 1-benzyl- and l-benzenesulfonyl-indole-2,3-dicarboxylates provided a mixture of the corresponding 5-bromoindole and 6-bromoindole derivatives. However, methyl l-trifluoromethanesulfonylindole-2,3-dicarboxylate gave methyl 6-bromo-1-trifluoromethanesulfonylindole-2,3-dicarboxylate as a major product.