J. Youziel, A. Akhbar, Q. Aziz
Jan 28, 2014
Citations
0
Influential Citations
26
Citations
Journal
Organic & biomolecular chemistry
Abstract
Bromo- and thiomaleimides are shown to serve as highly effective quenchers of a covalently attached fluorophore. Reactions with thiols that lead to removal of the maleimide conjugation, or detachment of the fluorophore from the maleimide, result in 'turn-on' of the fluorescence. These reagents thus offer opportunities in thiol sensing and intracellular reporting.