Edward Settel
Jan 1, 1959
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Journal of the American Geriatrics Society
Abstract
In the search for antihistaminic drugs with greater effectiveness and low toxicity, a new family of piperazine compounds was recently synthesized (1). One of them, chemically constituted as 1-p-chlorobenzhydryl-4-p-tertiary butylhenzyl-piperazine hydrochloride, was subjected to intensive clinical investigation. Its generic name is buclizine. Besides exhibiting relatively prolonged duration of antihistaminic activity (2), buclizine also proved to be an effective agent in controlling the nausea and vomiting of pregnancy (3-5), motion sickness (6) and labyrinthine disturbances. Many of the clinicians investigating buclizine observed that when the medication was given for other indications there was often a noticeable tranquilizing effect. This study was undertaken to evaluate the ataraxic properties of buolizine' in a series of 50 agitated patients divided into 2 groups (Table 1). Group I consisted of 21 hospitalized geriatric patients with mild or severe senile agitation; and Group II, 29 patients seen in general practice who had anxiety-tension or anxiety-depression syndromes.